After retiring from playing, he immediately jumped into the coaching world and started out with former MLS side Chivas USA. After returning to Mexico, Sanchez served as an assistant with a number of teams, including Puebla, while he held the reins at lower league Real Cuautitlán too.

In late-2017, Sanchez joined the newly-unveiled Las Vegas Lights of the United Soccer League, initially as an assistant coach to his father, Jose Luis Sanchez Sola (commonly known as Chelis). Early in the campaign, Chelis took over as Technical Director and Sanchez served as Head Coach until the end of the season. From there, he was appointed Head Coach at Tlaxcala back in his native Mexico and also held the top job at CD Proas in 2022. The following year, he returned to the Las Vegas Lights and was at the helm for the 2023 season. In the process, he became the first person to serve as a Head Coach in the second tier of both Mexico and the United States.

"For us, the objective is very clear: to build the best organization we can, and the appointment of Isidro is another example of our commitment to that," says Ricardo Pasquel, General Manager and President of York United FC.

"He brings plenty of experience and will contribute greatly to our technical staff. There's strength in numbers and, particularly as we approach such a crucial time of our season, every single advantage we can glean is potentially lucrative. Helping our coaching group as much as possible is integral to this club succeeding and we feel Isidro is another jigsaw piece that we need as we look to complete the puzzle."